Hexon peptides of type 2, 3, and 5 adenoviruses and their relationship to hexon structure
نویسندگان
چکیده
منابع مشابه
Hexon peptides of type 2, 3, and 5 adenoviruses and their relationship to hexon structure.
Peptides of hexons from type 2 and 5 (subgroup III) and type 3 (subgroup I) adenoviruses were produced by treatment with cyanogen bromide and were separated by isoelectric focusing in polyacrylamide gels containing 8 M urea. Peptides with identical isoelectric points, but from different hexon types, were considered to have structural similarities. According to this criterion for chemical relate...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses
The use of adenovirus serotype 5 (Ad5) vectors in the clinical setting is severely hampered by the profound liver tropism observed after intravascular delivery coupled with the pronounced inflammatory and innate immune response elicited by these vectors. Liver transduction by circulating Ad5 virions is mediated by a high-affinity interaction between the capsid hexon protein and blood coagulatio...
متن کاملIdentification of Adenovirus Serotype 5 Hexon Regions
24 Most of an intravenous dose of species C adenovirus serotype 5 (Ad5) is 25 destroyed by liver Kupffer cells. In contrast, another species C virus, Ad6, evades these 26 cells to mediate more efficient liver gene delivery. Given that this difference in Kupffer 27 cell interaction is mediated by the hypervariable (HVR) loops of the virus hexon protein, 28 we genetically modified each of the sev...
متن کاملMolecular weight of Adenovirus type 2 hexon polypeptide.
The fully dissociated hexon polypeptide of adenovirus type 2 has a molecular weight of 129,000 (+/-10,000) daltons as determined by high-speed sedimentation equilibrium in 6 m guanidine.
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1975
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.15.4.898-905.1975